![]() An additional wash-out phase was assigned to subjects prior to completing the study with the alternate test dentifrice.Īnalyses of log10-transformed microbial counts indicated no statistical differences in the baseline samples from each oral site (P > 0.05), while brushing with the zinc citrate dentifrice resulted in a significant reduction in bacteria in each post-brushing oral site versus the control paste (P < 0.05). Subjects brushed with the test formulation they used in the previous 13 days, prior to providing additional samples at 5-h post-brushing for microbial assessments. On the 14th day, they arrived at the dental clinic prior to oral hygiene and provided samples similar to baseline samples for microbiological examinations. ![]() Subjects brushed twice daily with a randomly assigned test dentifrice for the next 13 days. ![]() The present cross-over design clinical study compared the effects of brushing with a recently formulated dentifrice with 1% zinc citrate to a control dentifrice on oral bacteria found in oral niches.Ī total of 35 adults completed a 1-week wash-out phase prior to providing baseline samples of dental plaque on the teeth, gums, saliva and scrapings from cheeks and tongue to quantify anaerobic bacteria. The effects of routine use of these formulations on the microorganisms found in the distinct regions of the human mouth remain unexplored. Clinical studies with dentifrices formulated with antimicrobial ingredients typically examine the effects of their use on clinical parameters of dental plaque and gingivitis.
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